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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50006986
Substrate
n/a
Meas. Tech.
ChEMBL_201262 (CHEMBL804880)
IC50
3.2±n/a nM
Citation
 Wilson, AA; Dannals, RF; Ravert, HT; Sonders, MS; Weber, E; Wagner, HN Radiosynthesis of sigma receptor ligands for positron emission tomography: 11C- and 18F-labeled guanidines. J Med Chem 34:1867-70 (1991) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50006986
Synonyms:
CHEMBL442356 | N-Adamantan-1-yl-N'-(4-fluoro-2-methyl-phenyl)-guanidine
Type:
Small organic molecule
Emp. Form.:
C18H24FN3
Mol. Mass.:
301.4017
SMILES:
Cc1cc(F)ccc1N=C(N)NC12CC3CC(CC(C3)C1)C2 |w:8.8,TLB:19:18:21:14.13.15,19:14:21:18.20.17,15:16:20:14.13.19,THB:15:14:20:16.21.17|
Structure:
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