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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50007052
Substrate
n/a
Meas. Tech.
ChEBML_3863
IC50
6±n/a nM
Citation
 Bird, na; Bruneau, P; Crawley, GC; Edwards, MP; Foster, SJ; Girodeau, JM; Kingston, JF; McMillan, RM (Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity. J Med Chem 34:2176-86 (1991) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
5-LO | 5-lipoxygenase | Alox5 | Arachidonate 5-lipoxygenase | LOX5_MOUSE
Type:
PROTEIN
Mol. Mass.:
77961.27
Organism:
Mus musculus
Description:
ChEMBL_675639
Residue:
674
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGAVDSYDVTVDEELGEIYLVKIEKRKYWLHDDWYLKYITLKTPHGDYIEFPCYRWITGEGEIVLRDGRAKLARDDQIHILKQHRRKELEARQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTALPPKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGESNPIFLPTDSKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDSTEDIPFYFYRDDGLLVWEAIQSFTMEVVSIYYENDQVVEEDQELQDFVKDVYVYGMRGKKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50007052
Synonyms:
1-[3-(3-Phenyl-allyloxy)-phenyl]-1-thiazol-2-yl-propan-1-ol | CHEMBL70054
Type:
Small organic molecule
Emp. Form.:
C21H21NO2S
Mol. Mass.:
351.462
SMILES:
CCC(O)(c1nccs1)c1cccc(OC\C=C\c2ccccc2)c1
Structure:
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