Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50007421
Substrate
n/a
Meas. Tech.
ChEMBL_61750 (CHEMBL676057)
IC50
43±n/a nM
Citation
 Iorio, MA; Frigeni, V; Bowman, ER; Harris, LS; May, EL; Aceto, MD Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds. J Med Chem 34:194-7 (1991) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50007421
Synonyms:
CHEMBL59245 | Propionic acid 1-[4-(4-fluoro-phenyl)-4-oxo-butyl]-3-methyl-4-phenyl-piperidin-4-yl ester
Type:
Small organic molecule
Emp. Form.:
C25H30FNO3
Mol. Mass.:
411.509
SMILES:
CCC(=O)O[C@]1(CCN(CCCC(=O)c2ccc(F)cc2)CC1C)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: