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Target
Platelet-activating factor receptor
Ligand
BDBM50002831
Substrate
n/a
Meas. Tech.
ChEBML_86450
IC50
1500±n/a nM
Citation
 Piwinski, JJ; Wong, JK; Green, MJ; Ganguly, AK; Billah, MM; West, RE; Kreutner, W Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines. J Med Chem 34:457-61 (1991) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50002831
Synonyms:
(2R,5R)-2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan | (2S,5S)-2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan | (E)-(1R,2R,3R,5R,12S,13R,16S)-16-Hydroxymethyl-5,9,12,13-tetramethyl-4-oxa-tricyclo[10.3.1.0*3,5*]hexadec-8-en-2-ol | (L 652731)2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan | 2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan | 2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan(L-652,731) | 2,5-Bis-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan(L-652731) | CHEMBL297624 | L-652731
Type:
Small organic molecule
Emp. Form.:
C22H28O7
Mol. Mass.:
404.4535
SMILES:
COc1cc(cc(OC)c1OC)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Structure:
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