Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50008285
Substrate
n/a
Meas. Tech.
ChEBML_54603
Ki
0.013000±n/a nM
Citation
 DeGraw, JI; Christie, PH; Colwell, WT; Sirotnak, FM Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin. J Med Chem 35:320-4 (1992) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50008285
Synonyms:
2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid | CHEMBL113799
Type:
Small organic molecule
Emp. Form.:
C23H26N6O5
Mol. Mass.:
466.4897
SMILES:
CCC(Cc1cnc2nc(N)nc(N)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Structure:
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