Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM50257228
Substrate
n/a
Meas. Tech.
ChEBML_1689663
Ki
0.130000±n/a nM
Citation
 McKinnie, SMK; Wang, W; Fischer, C; McDonald, T; Kalin, KR; Iturrioz, X; Llorens-Cortes, C; Oudit, GY; Vederas, JC Synthetic Modification within the"RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation. J Med Chem 60:6408-6427 (2017) [PubMed]  Article 
Target
Name:
Apelin receptor
Synonyms:
APJ_RAT | Agtrl1 | Angiotensin receptor-like 1 | Apelin receptor | Apj | Aplnr | B78 | G-protein coupled receptor APJ | GPCR34
Type:
PROTEIN
Mol. Mass.:
42351.61
Organism:
Rattus norvegicus
Description:
ChEMBL_10710
Residue:
377
Sequence:
MEDDGYNYYGADNQSECDYADWTPSGALIPAIYILVFLLGTTGNGLVLWTVFWSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDIPENSTKTQCYMDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFIIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPCDFDSFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPHSSSAEKSASYSSGHSQGPGPNMCKGGEPMHEKSIPYSQETLVD
  
Inhibitor
Name:
BDBM50257228
Synonyms:
CHEMBL4077740
Type:
Small organic molecule
Emp. Form.:
C68H108BrN23O16
Mol. Mass.:
1583.634
SMILES:
CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)N(CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)NC(C)(C)C(=O)N[C@@H](Cc1ccc(Br)cc1)C(O)=O |r|
Structure:
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