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Target
D(2) dopamine receptor
Ligand
BDBM50008786
Substrate
n/a
Meas. Tech.
ChEMBL_62415 (CHEMBL675740)
Ki
0.770000±n/a nM
Citation
 Bishop, JE; Mathis, CA; Gerdes, JM; Whitney, JM; Eaton, AM; Mailman, RB Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors. J Med Chem 34:1612-24 (1991) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50008786
Synonyms:
CHEMBL43506 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-3-(2-fluoro-ethyl)-2-hydroxy-5,6-dimethoxy-benzamide
Type:
Small organic molecule
Emp. Form.:
C18H27FN2O4
Mol. Mass.:
354.4164
SMILES:
CCN1CCC[C@H]1CNC(=O)c1c(O)c(CCF)cc(OC)c1OC
Structure:
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