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TargetThromboxane A2 Synthase (P450 TxA2)
LigandBDBM50008796
Substrate/Competitorn/a
Meas. Tech.ChEMBL_210274
IC50 165±n/a nM
Citation Bhagwat, SSGude, CCohen, DSLee, WFurness, PClarke, FH Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 1. (+/-)-(3-pyridinylbicycloheptyl)alkanoic acids. J Med Chem34:1790-7 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thromboxane A2 Synthase (P450 TxA2)
Name:Thromboxane-A synthase
Synonyms:Cytochrome P450 5A1 | P450 TxA2 | TXA synthase | TXS | Thromboxane A2 Synthase | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:Enzyme
Mol. Mass.:60524.67
Organism:Homo sapiens (Human)
Description:P24557
Residue:533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50008796
NameBDBM50008796
Synonyms:8-(3-Pyridin-3-yl-bicyclo[2.2.1]hept-2-yl)-oct-6-enoic acid | CHEMBL51949
TypeSmall organic molecule
Emp. Form.C20H27NO2
Mol. Mass.313.4339
SMILESOC(=O)CCCC\C=C/C[C@@H]1C2CCC(C2)C1c1cccnc1 |THB:9:10:15:13.12|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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