Target
Renin
Ligand
BDBM50009899
Substrate
n/a
Meas. Tech.
ChEMBL_195954 (CHEMBL806849)
IC50
61±n/a nM
Citation
 Doherty, AMKaltenbronn, JSHudspeth, JPRepine, JTRoark, WHSircar, ITinney, FJConnolly, CJHodges, JCTaylor, MD New inhibitors of human renin that contain novel replacements at the P2 site. J Med Chem 34:1258-71 (1991) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50009899
Synonyms:
3-Hydroxy-4-[3-(3H-imidazol-4-yl)-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-propionylamino]-6-methyl-heptanoic acid (2-methyl-butyl)-amide | CHEMBL22411
Type:
Small organic molecule
Emp. Form.:
C43H53N5O4
Mol. Mass.:
703.912
SMILES:
CCC(C)CNC(=O)C[C@H](O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1cccc2ccccc12)Cc1cccc2ccccc12
Structure:
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