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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50027084
Substrate
n/a
Meas. Tech.
ChEMBL_1698288 (CHEMBL4049178)
Ki
0.112202±n/a nM
Citation
 Durek, T; Cromm, PM; White, AM; Schroeder, CI; Kaas, Q; Weidmann, J; Ahmad Fuaad, A; Cheneval, O; Harvey, PJ; Daly, NL; Zhou, Y; Dellsén, A; Österlund, T; Larsson, N; Knerr, L; Bauer, U; Kessler, H; Cai, M; Hruby, VJ; Plowright, AT; Craik, DJ Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. J Med Chem 61:3674-3684 (2018) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:
Enzyme
Mol. Mass.:
34717.23
Organism:
Homo sapiens (Human)
Description:
Q01726
Residue:
317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
  
Inhibitor
Name:
BDBM50027084
Synonyms:
Melatonan
Type:
Small organic molecule
Emp. Form.:
C50H69N15O9
Mol. Mass.:
1024.178
SMILES:
CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r|
Structure:
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