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Target
Lysyl oxidase homolog 2
Ligand
BDBM50266786
Substrate
n/a
Meas. Tech.
ChEBML_1701368
IC50
120±n/a nM
Citation
 Rowbottom, MW; Bain, G; Calderon, I; Lasof, T; Lonergan, D; Lai, A; Huang, F; Darlington, J; Prodanovich, P; Santini, AM; King, CD; Goulet, L; Shannon, KE; Ma, GL; Nguyen, K; MacKenna, DA; Evans, JF; Hutchinson, JH Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem 60:4403-4423 (2017) [PubMed]  Article 
Target
Name:
Lysyl oxidase homolog 2
Synonyms:
1.4.3.13 | LOXL2_RAT | Loxl2 | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2
Type:
PROTEIN
Mol. Mass.:
87182.46
Organism:
Rattus norvegicus
Description:
ChEMBL_117513
Residue:
776
Sequence:
MEIPFGSCLYSCLALLVLLPSLSLAQYESWPYQLQYPEYFQQPPPEHHQHQVPSDVVKIQVRLAGQKRKHNEGRVEVYYEGQWGTVCDDDFSIHAAHVVCREVGYVEAKSWTASSSYGPGEGPIWLDNIYCTGKESTLAACSSNGWGVTDCKHPEDVGVVCSEKRIPGFKFDNSLINQIESLNIQVEDIRIRPILSAFRHRKPVTEGYVEVKEGKAWKQICDKHWTAKNSHVVCGMFGFPAEKTYNPKAYKTFASRRKLRYWKFSMNCTGTEAHISSCKLGPPMFRDPVKNATCENGQPAVVSCVPSQIFSPDGPSRFRKAYKPEQPLVRLRGGAQVGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGTAKEAVTGSRLGQGIGPIHLNEVQCTGTEKSIIDCKLNTESQGCNHEEDAGVRCNIPIMGFQKKVRLNGGRNPYEGRVEVLTERNGSLVWGNVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGNIFANKVIMSGVKCSGTELSLAHCRHDEEVVCPEGGVQYGAGVACSETAPDLVLNAEIVQQTAYLEDRPMALLQCAMEENCLSASAVHTDPTRGHRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTYYDLLSLNGTKVAEGHKASFCLEDTECEGDIQKSYECANFGEQGITMGCWDMYRHDIDCQWIDITDVPPGDYLFQVVINPNYEVPESDFSNNIMKCRSRYDGYRIWMYNCHVGGAFSEETEQKFEHFSGLLNNQLSVQ
  
Inhibitor
Name:
BDBM50266786
Synonyms:
CHEMBL4063337
Type:
Small organic molecule
Emp. Form.:
C17H19ClFN3O3
Mol. Mass.:
367.802
SMILES:
Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1 |r|
Structure:
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