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Target
VIM-2 type metallo-beta-lactamase
Ligand
BDBM50267417
Substrate
n/a
Meas. Tech.
ChEMBL_1702770 (CHEMBL4054003)
IC50
34000±n/a nM
Citation
 Skagseth, S; Akhter, S; Paulsen, MH; Muhammad, Z; Lauksund, S; Samuelsen, Ø; Leiros, HS; Bayer, A Metallo-?-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding. Eur J Med Chem 135:159-173 (2017) [PubMed]  Article 
Target
Name:
VIM-2 type metallo-beta-lactamase
Synonyms:
VIM-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28318.00
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
266
Sequence:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
  
Inhibitor
Name:
BDBM50267417
Synonyms:
CHEMBL4095160
Type:
Small organic molecule
Emp. Form.:
C17H27O4PS
Mol. Mass.:
358.433
SMILES:
CCOP(=O)(OCC)C(CCCc1ccccc1)CSC(C)=O
Structure:
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