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Target
Kallikrein-7
Ligand
BDBM50275970
Substrate
n/a
Meas. Tech.
ChEMBL_1715073 (CHEMBL4125122)
IC50
>30000±n/a nM
Citation
 Murafuji, H; Sugawara, H; Goto, M; Oyama, Y; Sakai, H; Imajo, S; Tomoo, T; Muto, T Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones. Bioorg Med Chem 26:3639-3653 (2018) [PubMed]  Article 
Target
Name:
Kallikrein-7
Synonyms:
3.4.21.117 | KLK7_MOUSE | Kallikrein-7 | Klk7 | Prss6 | Scce | Serine protease 6 | Stratum corneum chymotryptic enzyme | Thymopsin
Type:
PROTEIN
Mol. Mass.:
27264.75
Organism:
Mus musculus
Description:
ChEMBL_118155
Residue:
249
Sequence:
MGVWLLSLITVLLSLALETAGQGERIIDGYKCKEGSHPWQVALLKGNQLHCGGVLVDKYWVLTAAHCKMGQYQVQLGSDKIGDQSAQKIKATKSFRHPGYSTKTHVNDIMLVRLDEPVKMSSKVEAVQLPEHCEPPGTSCTVSGWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLGKTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQGLVSWGTYPCGQPNDPGVYTQVCKYKRWVMETMKTHR
  
Inhibitor
Name:
BDBM50275970
Synonyms:
CHEMBL4125816
Type:
Small organic molecule
Emp. Form.:
C26H29F2N7O2
Mol. Mass.:
509.551
SMILES:
CN(C)\N=C1\CN(CC(=O)Nc2cccc(c2)-c2cnn(C)c2)C(=O)C(Cc2c(F)cccc2F)CN1
Structure:
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