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TargetAngiotensin II receptor (AT-1) type-1
LigandBDBM50228272
Substrate/Competitorn/a
Meas. Tech.ChEMBL_36495
IC50 2.1±n/a nM
Citation Spear, KLBrown, MSReinhard, EJMcMahon, EGOlins, GMPalomo, MAPatton, DR Conformational restriction of angiotensin II: cyclic analogues having high potency. J Med Chem33:1935-40 (1990) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Angiotensin II receptor (AT-1) type-1
Name:Angiotensin II receptor (AT-1) type-1
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 36330
Components:This complex has 2 components.
Component 1
Name:Angiotensin II receptor (AT-1) type-1
Synonyms:ANGIOTENSIN AT1 | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | Type-1A angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40910.53
Organism:RAT
Description:ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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Component 2
Name:Angiotensin II receptor (AT-1) type-1
Synonyms:AT1B | AT3 | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | Type-1B angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40929.44
Organism:RAT
Description:Angiotensin II AT1B 0 RAT::P29089
Residue:359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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  Blast E-value cutoff:
BDBM50228272
NameBDBM50228272
Synonyms:CHEMBL411997
TypeSmall organic molecule
Emp. Form.C47H63N13O12S2
Mol. Mass.1066.213
SMILESN[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSSCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |wU:59.63,46.47,9.8,31.31,1.0,wD:20.19,27.44,63.66,(4.96,9.59,;6.07,9.07,;7.34,9.95,;7.21,11.48,;6.1,12.01,;8.22,12.19,;6.2,7.53,;7.31,7.01,;4.93,6.66,;5.06,5.12,;6.45,4.47,;7.72,5.35,;9.11,4.69,;10.38,5.57,;11.77,4.91,;12.78,5.62,;11.87,3.69,;3.79,4.24,;2.68,4.77,;3.92,2.71,;2.65,1.83,;1.49,2.85,;,3.22,;-1.5,2.85,;-2.65,1.83,;-3.19,.39,;-3.01,-1.14,;-2.13,-2.4,;-.77,-3.12,;.77,-3.12,;1.06,-4.32,;2.13,-2.4,;3.16,-3.57,;4.67,-3.26,;5.69,-4.41,;7.19,-4.11,;7.68,-2.65,;8.89,-2.4,;6.66,-1.5,;5.15,-1.8,;3.01,-1.14,;3.19,.39,;4.41,.54,;-3.16,-3.57,;-4.37,-3.32,;-2.67,-5.03,;-3.69,-6.18,;-3.2,-7.64,;-1.69,-7.95,;-1.07,-9.35,;.46,-9.17,;.76,-7.66,;-.58,-6.9,;-5.2,-5.88,;-5.59,-4.71,;-6.21,-7.04,;-5.86,-8.52,;-7.18,-9.31,;-8.34,-8.29,;-7.73,-6.88,;-8.51,-5.55,;-9.74,-5.56,;-7.74,-4.21,;-8.52,-2.88,;-7.75,-1.54,;-8.52,-.21,;-7.76,1.12,;-8.54,2.46,;-10.08,2.45,;-10.84,1.11,;-10.06,-.22,;-10.06,-2.88,;-10.67,-3.95,;-10.68,-1.82,)|
Structure
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