Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50015920
Substrate
n/a
Meas. Tech.
ChEBML_63651
IC50
200±n/a nM
Citation
 Finke, PE; Ashe, BM; Knight, WB; Maycock, AL; Navia, MA; Shah, SK; Thompson, KR; Underwood, DJ; Weston, H; Zimmerman, M Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides. J Med Chem 33:2522-8 (1990) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50015920
Synonyms:
3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-tert-butyl-benzyl ester | CHEMBL85215
Type:
Small organic molecule
Emp. Form.:
C22H27NO8S
Mol. Mass.:
465.517
SMILES:
CO[C@@H]1[C@@H]2N(C1=O)C(C(=O)OCc1ccc(cc1)C(C)(C)C)=C(COC(C)=O)CS2(=O)=O |t:23|
Structure:
Search PDB for entries with ligand similarity: