Reaction Details Report a problem with these data
Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM50016686
Substrate
n/a
Meas. Tech.
ChEBML_219
IC50
600±n/a nM
Citation
 Huang, FC; Shoupe, TS; Lin, CJ; Lee, TD; Chan, WK; Tan, J; Schnapper, M; Suh, JT; Gordon, RJ; Sonnino, PA Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis. J Med Chem 32:1836-42 (1989) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
12-LOX | 12/15-lipoxygenase | 15-LOX | Alox12l | Alox15 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, leukocyte-type | Arachidonate omega-6 lipoxygenase | LOX15_RAT
Type:
PROTEIN
Mol. Mass.:
75377.59
Organism:
Rattus norvegicus
Description:
ChEMBL_1510006
Residue:
663
Sequence:
MGVYRIRVSTGDSKYAGSNNEVYLWLVGQHGEASLGKLLRPCRDSEAEFKVDVSEYLGPLLFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQGRSILSLPEGTGCTVVEDSQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISDLPVDQRFREDKRIEFEASQVIGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTPSDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLMAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKAMSTGGGGHLDLLKQAGAFLTYCSLCPPDDLAERGLLDIETCFYAKDALRLWQIMNRYVVGMFNLHYKTDKAVQDDYELQSWCREITDIGLQGAQDRGFPTSLQSRAQACYFITMCIFTCTAQHSSVHLGQLDWFYWVPNAPCTMRLPPPTTKEATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENSVAI
  
Inhibitor
Name:
BDBM50016686
Synonyms:
CHEMBL54013 | N-Hydroxy-3-phenyl-N-(3-phenyl-propyl)-propionamide
Type:
Small organic molecule
Emp. Form.:
C18H21NO2
Mol. Mass.:
283.3648
SMILES:
ON(CCCc1ccccc1)C(=O)CCc1ccccc1
Structure:
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