Reaction Details Report a problem with these data
Target
Papain
Ligand
BDBM50018174
Substrate
n/a
Meas. Tech.
ChEBML_152650
pH
5±n/a
Ki
700±n/a nM
Comments
extracted
Citation
 Silver, MS; Haskell, JH Acid-sensitive latent inhibitors for proteolytic enzymes: synthesis and characterization. J Med Chem 32:1253-9 (1989) [PubMed]  Article 
Target
Name:
Papain
Synonyms:
Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I
Type:
Enzyme
Mol. Mass.:
38923.01
Organism:
Carica papaya
Description:
Papain was purchased from Sigma, Germany.
Residue:
345
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
  
Inhibitor
Name:
BDBM50018174
Synonyms:
CHEMBL283109 | N-{2-[(2-Acetylamino-propionyl)-hydrazono]-1-benzyl-ethyl}-benzamide
Type:
Small organic molecule
Emp. Form.:
C21H24N4O3
Mol. Mass.:
380.4403
SMILES:
C[C@H](NC(C)=O)C(=O)NN=CC(Cc1ccccc1)NC(=O)c1ccccc1 |w:9.8|
Structure:
Search PDB for entries with ligand similarity: