Target
Dihydrofolate reductase
Ligand
BDBM50018478
Substrate
n/a
Meas. Tech.
ChEMBL_54744 (CHEMBL667195)
Ki
0.500000±n/a nM
Citation
 Roth, BTidwell, MYFerone, RBaccanari, DPSigel, CWDeAngelis, DElwell, LP 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms. J Med Chem 32:1949-58 (1989) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (F31V) | dfrA17
Type:
n/a
Mol. Mass.:
17532.46
Organism:
Escherichia coli
Description:
n/a
Residue:
157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
  
Inhibitor
Name:
BDBM50018478
Synonyms:
5-(3-Ethoxy-4,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL23609 | TCMDC-137664
Type:
Small organic molecule
Emp. Form.:
C15H20N4O3
Mol. Mass.:
304.3443
SMILES:
CCOc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: