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Target
Cyclin-dependent kinase 6
Ligand
BDBM50110183
Substrate
n/a
Meas. Tech.
ChEMBL_1746078 (CHEMBL4180588)
IC50
1.9±n/a nM
Citation
 Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors. Bioorg Med Chem Lett 27:5332-5336 (2017) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM50110183
Synonyms:
Abemaciclib | LY-2835219 | US10626107, Example LY2835219 | US10662186, Compound LY2835219 | US10696678, Example LY2835219 | US10988476, Compound LY2835219 | US11053238, LY2835219 | US11091476, Example LY2835219 | US11351170, Example Abemaciclib
Type:
Small organic molecule
Emp. Form.:
C27H32F2N8
Mol. Mass.:
506.5934
SMILES:
CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1
Structure:
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