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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50181821
Substrate
n/a
Meas. Tech.
ChEMBL_1748019 (CHEMBL4182529)
Ki
6.9±n/a nM
Citation
 Yeon, SK; Choi, JW; Park, JH; Lee, YR; Kim, HJ; Shin, SJ; Jang, BK; Kim, S; Bahn, YS; Han, G; Lee, YS; Pae, AN; Park, KD Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy. Bioorg Med Chem 26:232-244 (2018) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50181821
Synonyms:
CHEMBL202071 | O-(p-trifluoromethyl)benzyl-tyramine
Type:
Small organic molecule
Emp. Form.:
C16H16F3NO
Mol. Mass.:
295.2995
SMILES:
NCCc1ccc(OCc2ccc(cc2)C(F)(F)F)cc1
Structure:
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