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Target
Somatostatin receptor type 1/2/3/4/5
Ligand
BDBM50020207
Substrate
n/a
Meas. Tech.
ChEMBL_200345 (CHEMBL807247)
IC50
19408±n/a nM
Citation
 Kazmierski, W; Wire, WS; Lui, GK; Knapp, RJ; Shook, JE; Burks, TF; Yamamura, HI; Hruby, VJ Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors. J Med Chem 31:2170-7 (1988) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 1/2/3/4/5
Synonyms:
Somatostatin receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 200351
Components:
This complex has 5 components.
Component 1
Name:
Somatostatin receptor type 1
Synonyms:
SOMATOSTATIN SST1 | SRIF-2 | SS1R | SSR1_RAT | Somatostatin receptor | Somatostatin receptor type 1 | Sstr1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42752.93
Organism:
RAT
Description:
SOMATOSTATIN SST1 SSTR1 RAT::P28646
Residue:
391
Sequence:
MFPNGTAPSPTSSPSSSPGGCGEGVCSRGPGSGAADGMEEPGRNSSQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCASRISTL
  
Component 2
Name:
Somatostatin receptor type 3
Synonyms:
SOMATOSTATIN SST3 | SSR3_RAT | Somatostatin receptor | Somatostatin receptor 3 | Somatostatin receptor type 3 | Sstr3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47161.54
Organism:
RAT
Description:
SOMATOSTATIN SST3 SSTR3 RAT::P30936
Residue:
428
Sequence:
MAAVTYPSSVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQPGPSGQQQRPCTGTAKEQQLLPQEATAGDKASTLSHL
  
Component 3
Name:
Somatostatin receptor type 4
Synonyms:
SOMATOSTATIN SST4 | SSR4_RAT | Somatostatin receptor | Somatostatin receptor type 4 | Sstr4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42096.84
Organism:
RAT
Description:
SOMATOSTATIN SST4 SSTR4 RAT::P30937
Residue:
384
Sequence:
MNTPATLPLGGEDTTWTPGINASWAPDEEEDAVRSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGPGCICPPLPCQQEPMQAEPACKRVPFTKTTTF
  
Component 4
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS2R | SSR2_RAT | Somatostatin receptor | Somatostatin receptor 2 | Somatostatin receptor type 2 | Sstr2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41212.21
Organism:
RAT
Description:
SOMATOSTATIN SST2 SSTR2 RAT::P30680
Residue:
369
Sequence:
MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Component 5
Name:
Somatostatin receptor type 5
Synonyms:
SOMATOSTATIN SST5 | SSR5_RAT | Somatostatin receptor | Somatostatin receptor type 5 | Sstr5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39986.50
Organism:
RAT
Description:
SOMATOSTATIN SST5 SSTR5 RAT::P30938
Residue:
363
Sequence:
MEPLSLASTPSWNASAASSGNHNWSLVGSASPMGARAVLVPVLYLLVCTVGLSGNTLVIYVVLRHAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKMASAAVWVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRRSEPKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKVLCLRRGYGMEDADAIEPRPDKSGRPQATLPTRSCEANGLMQTSRI
  
Inhibitor
Name:
BDBM50020207
Synonyms:
CHEMBL2369473 | Gly-D-Ticc(-Cys-Tyr-D-Trp-Orn-Thr-Pen-)Thr-NH2
Type:
Small organic molecule
Emp. Form.:
C53H70N12O12S2
Mol. Mass.:
1131.326
SMILES:
[H][C@]1(NC(=O)[C@H](CCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CSSC(C)(C)[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)NC(=O)[C@H]1Cc2ccccc2CN1C(=O)CN)[C@@H](C)O
Structure:
Search PDB for entries with ligand similarity: