Reaction Details Report a problem with these data
Target
DNA-(apurinic or apyrimidinic site) endonuclease
Ligand
BDBM114257
Substrate
n/a
Meas. Tech.
ChEMBL_1750389 (CHEMBL4185149)
IC50
400±n/a nM
Citation
 Laev, SS; Salakhutdinov, NF; Lavrik, OI Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1). Bioorg Med Chem 25:2531-2544 (2017) [PubMed]  Article 
Target
Name:
DNA-(apurinic or apyrimidinic site) endonuclease
Synonyms:
APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1
Type:
Protein
Mol. Mass.:
35560.12
Organism:
Homo sapiens (Human)
Description:
P27695
Residue:
318
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
  
Inhibitor
Name:
BDBM114257
Synonyms:
3,8,9,10-tetrahydroxypyran[3,2-c]isochromene-2,6-quinone | 3,8,9,10-tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione | 3,8,9,10-tetrahydroxypyrano[3,2-c]isochromene-2,6-dione | 3,8,9,10-tetrakis(oxidanyl)pyrano[3,2-c]isochromene-2,6-dione | Galloflavin | MLS000737267 | SMR000528495 | cid_54683147
Type:
Small organic molecule
Emp. Form.:
C12H6O8
Mol. Mass.:
278.1712
SMILES:
Oc1cc2c(c(O)c1O)c1oc(=O)c(O)cc1oc2=O
Structure:
Search PDB for entries with ligand similarity: