Target
DNA-(apurinic or apyrimidinic site) endonuclease
Ligand
BDBM50066721
Substrate
n/a
Meas. Tech.
ChEMBL_1750397 (CHEMBL4185157)
IC50
80±n/a nM
Citation
 Laev, SSSalakhutdinov, NFLavrik, OI Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1). Bioorg Med Chem 25:2531-2544 (2017) [PubMed]  Article 
Target
Name:
DNA-(apurinic or apyrimidinic site) endonuclease
Synonyms:
APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1
Type:
Protein
Mol. Mass.:
35560.12
Organism:
Homo sapiens (Human)
Description:
P27695
Residue:
318
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
  
Inhibitor
Name:
BDBM50066721
Synonyms:
1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one | 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one | 1-(2-diethylaminoethylamino)-4-(hydroxymethyl)thioxanthen-9-one | 1-{[2-(diethylamino)ethyl]amino}-4-(hydroxymethyl)-9H-thioxanthen-9-one | CHEMBL22077 | Hycanthon | Hycanthone | Lucanthone metabolite
Type:
Small organic molecule
Emp. Form.:
C20H24N2O2S
Mol. Mass.:
356.482
SMILES:
CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12
Structure:
Search PDB for entries with ligand similarity: