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Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ligand
BDBM50457942
Substrate
n/a
Meas. Tech.
ChEMBL_1761125 (CHEMBL4196372)
IC50
115900±n/a nM
Citation
 Ch?o?-Rzepa, G; Jankowska, A; ?lusarczyk, M; ?wierczek, A; Pociecha, K; Wyska, E; Bucki, A; Gawalska, A; Ko?aczkowski, M; Paw?owski, M Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation. Eur J Med Chem 146:381-394 (2018) [PubMed]  Article 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:
Enzyme
Mol. Mass.:
55514.96
Organism:
Homo sapiens (Human)
Description:
Q13946
Residue:
482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  
Inhibitor
Name:
BDBM50457942
Synonyms:
CHEMBL4217546
Type:
Small organic molecule
Emp. Form.:
C25H27N7O5
Mol. Mass.:
505.5258
SMILES:
Cn1c2nc(NCc3ccccc3)n(CCCC(=O)N\N=C\c3ccc(O)cc3O)c2c(=O)n(C)c1=O
Structure:
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