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Target
Endothelial lipase
Ligand
BDBM50458640
Substrate
n/a
Meas. Tech.
ChEMBL_1764452 (CHEMBL4199699)
IC50
100±n/a nM
Citation
 Hangeland, JJ; Abell, LM; Adam, LP; Jiang, J; Friends, TJ; Haque, LE; Neels, J; Onorato, JM; Chen, AYA; Taylor, DS; Yin, X; Harrity, TW; Basso, MD; Yang, R; Sleph, PG; Gordon, DA; Huang, CS; Wexler, RR; Finlay, HJ; Lawrence, RM PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor. ACS Med Chem Lett 9:673-678 (2018) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg
Type:
Protein
Mol. Mass.:
56643.58
Organism:
Mus musculus (Mouse)
Description:
Q9WVG5
Residue:
500
Sequence:
MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA
  
Inhibitor
Name:
BDBM50458640
Synonyms:
CHEMBL4203934
Type:
Small organic molecule
Emp. Form.:
C17H20Cl2N2O3
Mol. Mass.:
371.258
SMILES:
CCN1CC(C(=O)NC(C)CCc2ccc(Cl)c(Cl)c2)=C(O)C1=O |t:20|
Structure:
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