Target
Vitamin K-dependent protein C
Ligand
BDBM81818
Substrate
n/a
Meas. Tech.
ChEMBL_1765372 (CHEMBL4200619)
IC50
>50000±n/a nM
Citation
 Buckley, BJAboelela, AMinaei, EJiang, LXXu, ZAli, UFildes, KCheung, CYCook, SMJohnson, DCBachovchin, DACook, GMApte, MHuang, MRanson, MKelso, MJ 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. J Med Chem 61:8299-8320 (2018) [PubMed]  Article 
Target
Name:
Vitamin K-dependent protein C
Synonyms:
Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor
Type:
Enzyme
Mol. Mass.:
52067.73
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
461
Sequence:
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
  
Inhibitor
Name:
BDBM81818
Synonyms:
CAS_1794 | CHEMBL1909810 | HMA | NSC_1794
Type:
Small organic molecule
Emp. Form.:
C12H18ClN7O
Mol. Mass.:
311.771
SMILES:
NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1
Structure:
Search PDB for entries with ligand similarity: