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Target
Synaptic vesicular amine transporter
Ligand
BDBM50459619
Substrate
n/a
Meas. Tech.
ChEMBL_1766889 (CHEMBL4202136)
Ki
152±n/a nM
Citation
 Provencher, BA; Eshleman, AJ; Johnson, RA; Shi, X; Kryatova, O; Nelson, J; Tian, J; Gonzalez, M; Meltzer, PC; Janowsky, A Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem 61:9121-9131 (2018) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2
Type:
PROTEIN
Mol. Mass.:
55709.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_610810
Residue:
514
Sequence:
MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
  
Inhibitor
Name:
BDBM50459619
Synonyms:
CHEMBL4206824
Type:
Small organic molecule
Emp. Form.:
C19H29NO3
Mol. Mass.:
319.4385
SMILES:
COc1cc2CCN3CC(CC(C)C)C(O)CC3c2cc1OC
Structure:
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