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Target
Renin-1
Ligand
BDBM50022864
Substrate
n/a
Meas. Tech.
ChEBML_196286
IC50
1000±n/a nM
Citation
 Sham, HL; Bolis, G; Stein, HH; Fesik, SW; Marcotte, PA; Plattner, JJ; Rempel, CA; Greer, J Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen. J Med Chem 31:284-95 (1988) [PubMed]  Article 
Target
Name:
Renin-1
Synonyms:
Angiotensinogenase | Kidney renin | RENI1_MOUSE | Ren | Ren-1 | Ren1 | Renin | Renin-1
Type:
PROTEIN
Mol. Mass.:
44345.30
Organism:
Mus musculus
Description:
ChEMBL_685608
Residue:
402
Sequence:
MDRRRMPLWALLLLWSPCTFSLPTRTATFERIPLKKMPSVREILEERGVDMTRLSAEWGVFTKRPSLTNLTSPVVLTNYLNTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGSDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSWQITMKGVSVGSSTLLCEEGCAVVVDTGSSFISAPTSSLKLIMQALGAKEKRIEEYVVNCSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLCTLALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
  
Inhibitor
Name:
BDBM50022864
Synonyms:
Boc-Phe-(CH3)Ala-Leu-Val-Ile-His-OMe | CHEMBL318242
Type:
Small organic molecule
Emp. Form.:
C42H66N8O9
Mol. Mass.:
827.0216
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)OC
Structure:
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