Target
Acetylcholine receptor subunit alpha/beta/delta/gamma
Ligand
BDBM50023331
Substrate
n/a
Meas. Tech.
ChEMBL_143082 (CHEMBL748732)
IC50
1±n/a nM
Citation
 Kanne, DBAbood, LG Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids. J Med Chem 31:506-9 (1988) [PubMed]  Article 
Target
Name:
Acetylcholine receptor subunit alpha/beta/delta/gamma
Synonyms:
Acetylcholine receptor | Acetylcholine receptor protein alpha/beta/delta/gamma chain
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 143080
Components:
This complex has 4 components.
Component 1
Name:
Acetylcholine receptor subunit beta
Synonyms:
ACHB_TETCF | Acetylcholine receptor | CHRNB1
Type:
PROTEIN
Mol. Mass.:
56146.98
Organism:
Torpedo californica
Description:
EBI_19626
Residue:
493
Sequence:
MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLTLTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNNDGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEVTLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRKPLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLSVPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPVTTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVTLPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFLDASHNVPPDNPFA
  
Component 2
Name:
Acetylcholine receptor subunit gamma
Synonyms:
ACHG_TETCF | Acetylcholine receptor | CHRNG
Type:
PROTEIN
Mol. Mass.:
58151.68
Organism:
Torpedo californica
Description:
EBI_19662
Residue:
506
Sequence:
MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISLNEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVAYYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAEEGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYIINIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLIGKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEETPEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLYKDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGTLAIFLTGHFNQVPEFPFPGDPRKYVP
  
Component 3
Name:
Acetylcholine receptor subunit alpha
Synonyms:
ACHA_TETCF | Acetylcholine receptor | Acetylcholine receptor protein alpha chain | CHRNA1
Type:
PROTEIN
Mol. Mass.:
52735.09
Organism:
Torpedo californica
Description:
ChEMBL_216981
Residue:
461
Sequence:
MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQLIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNADGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKVSISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEKQENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAAEEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
  
Component 4
Name:
Acetylcholine receptor subunit delta
Synonyms:
ACHD_TETCF | Acetylcholine receptor | Acetylcholine receptor protein delta chain | chrnd
Type:
PROTEIN
Mol. Mass.:
59885.01
Organism:
Torpedo californica
Description:
ChEMBL_142744
Residue:
522
Sequence:
MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTLSNLISLKETDETLTSNVWMDHAWYDHRLTWNASEYSDISILRLPPELVWIPDIVLQNNNDGQYHVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEITMDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYLIIRRKPLFYVINFITPCVLISFLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLPETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILHMSRADESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPRIGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMFIITPVMVLGTIFIFVMGNFNHPPAKPFEGDPFDYSSDHPRCA
  
Inhibitor
Name:
BDBM50023331
Synonyms:
(+)-pyrido[3,4-b]homotropane | (+/-)-pyrido[3,4-b]homotropane | (-)-pyrido[3,4-b]homotropane | 4,13-Diaza-tricyclo[8.2.1.0*2,7*]trideca-2(7),3,5-triene | 4,13-Diaza-tricyclo[8.2.1.0*2,7*]trideca-2(7),3,5-triene(PHT) | CHEMBL149667
Type:
Small organic molecule
Emp. Form.:
C11H14N2
Mol. Mass.:
174.2423
SMILES:
C1CC2NC1CCc1ccncc21
Structure:
Search PDB for entries with ligand similarity: