Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50016326
Substrate
n/a
Meas. Tech.
ChEMBL_217876 (CHEMBL821982)
Ki
0.000±n/a nM
Citation
 Su, TL; Huang, JT; Chou, TC; Otter, GM; Sirotnak, FM; Watanabe, KA Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s). J Med Chem 31:1209-15 (1988) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50016326
Synonyms:
2-{4-[(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | CHEMBL428862
Type:
Small organic molecule
Emp. Form.:
C21H23N7O5
Mol. Mass.:
453.4512
SMILES:
Cc1c(CNc2ccc(cc2)C(=O)NC(CCC(O)=O)C(O)=O)cnc2nc(N)nc(N)c12
Structure:
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