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Target
Mu-type opioid receptor
Ligand
BDBM50463290
Substrate
n/a
Meas. Tech.
ChEMBL_1777971 (CHEMBL4234963)
Ki
7.2±n/a nM
Citation
 Sun, HJ; Wang, YH; Yuan, CM; Kong, LH; Xu, XJ; Wang, YJ; Wu, HH; Lin, C; Qian, YY; Huang, HM; Xiao, L; Liu, X; He, Q; Fang, SY; Xue, DQ; Yang, XC; Chen, H; Zheng, YL; Zheng, L; Yu, LQ; Xie, Q; Fu, W; Li, W; Liu, JG; Qiu, ZB; Shao, LM 7?-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg Med Chem 26:4254-4263 (2018) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50463290
Synonyms:
CHEMBL4241031
Type:
Small organic molecule
Emp. Form.:
C27H35NO5
Mol. Mass.:
453.5705
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@](C)(C1)OC(C)=O)ccc3OC |r,THB:10:9:17:5.6.4|
Structure:
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