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Target
Delta-type opioid receptor
Ligand
BDBM50463286
Substrate
n/a
Meas. Tech.
ChEMBL_1777973 (CHEMBL4234965)
Ki
59±n/a nM
Citation
 Sun, HJ; Wang, YH; Yuan, CM; Kong, LH; Xu, XJ; Wang, YJ; Wu, HH; Lin, C; Qian, YY; Huang, HM; Xiao, L; Liu, X; He, Q; Fang, SY; Xue, DQ; Yang, XC; Chen, H; Zheng, YL; Zheng, L; Yu, LQ; Xie, Q; Fu, W; Li, W; Liu, JG; Qiu, ZB; Shao, LM 7?-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg Med Chem 26:4254-4263 (2018) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50463286
Synonyms:
CHEMBL4239240
Type:
Small organic molecule
Emp. Form.:
C33H38F3NO4
Mol. Mass.:
569.6543
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@](C)(C1)C(O)c1ccc(cc1)C(F)(F)F)ccc3OC |r,THB:10:9:17:5.6.4|
Structure:
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