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Target
Angiotensin-converting enzyme
Ligand
BDBM50011192
Substrate
n/a
Meas. Tech.
ChEBML_34801
IC50
5.7±n/a nM
Citation
 Yanagisawa, H; Ishihara, S; Ando, A; Kanazaki, T; Miyamoto, S; Koike, H; Iijima, Y; Oizumi, K; Matsushita, Y; Hata, T Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives. J Med Chem 30:1984-91 (1987) [PubMed]  Article 
Target
Name:
Angiotensin-converting enzyme
Synonyms:
3.2.1.- | 3.4.15.1 | ACE | ACE_RABIT | Angiotensin-converting enzyme, soluble form | CD_antigen=CD143 | DCP1 | Dipeptidyl carboxypeptidase I | Kininase II
Type:
n/a
Mol. Mass.:
150405.15
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
1310
Sequence:
MGAAPGRRGPRLLRPPPPLLLLLLLLRPPPAALTLDPGLLPGDFAADEAGARLFASSYNSSAEQVLFRSTAASWAHDTNITAENARRQEEEALLSQEFAEAWGKKAKELYDPVWQNFTDPELRRIIGAVRTLGPANLPLAKRQQYNSLLSNMSQIYSTGKVCFPNKTASCWSLDPDLNNILASSRSYAMLLFAWEGWHNAVGIPLKPLYQEFTALSNEAYRQDGFSDTGAYWRSWYDSPTFEEDLERIYHQLEPLYLNLHAYVRRVLHRRYGDRYINLRGPIPAHLLGNMWAQSWESIYDMVVPFPDKPNLDVTSTMVQKGWNATHMFRVAEEFFTSLGLLPMPPEFWAESMLEKPEDGREVVCHASAWDFYNRKDFRIKQCTQVTMDQLSTVHHEMGHVQYYLQYKDQPVSLRRANPGFHEAIGDVLALSVSTPAHLHKIGLLDHVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPSSRYNFDWWYLRTKYQGICPPVVRNETHFDAGAKFHIPSVTPYIRYFVSFVLQFQFHQALCMEAGHQGPLHQCDIYQSTRAGAKLRAVLQAGCSRPWQEVLKDMVASDALDAQPLLDYFQPVTQWLQEQNERNGEVLGWPEYQWRPPLPNNYPEGIDLVTDEAEASRFVEEYDRSFQAVWNEYAEANWNYNTNITTEASKILLQKNMQIANHTLTYGNWARRFDVSNFQNATSKRIIKKVQDLQRAVLPVKELEEYNQILLDMETIYSVANVCRVDGSCLQLEPDLTNLMATSRKYDELLWVWTSWRDKVGRAILPYFPKYVEFTNKAARLNGYVDAGDSWRSMYETPTLEQDLERLFQELQPLYLNLHAYVGRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVAPFPSASTMDATEAMIKQGWTPRRMFEEADKFFISLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNMEDLVVVHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSINLLSSEGGGYEHDINFLMKMALDKIAFIPFSYLVDEWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPAPRSQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCKAAGHTGPLHTCDIYQSKEAGKRLADAMKLGYSKPWPEAMKVITGQPNMSASAMMNYFKPLMDWLLTENGRHGEKLGWPQYTWTPNSARSEGSLPDSGRVNFLGMNLDAQQARVGQWVLLFLGVALLLASLGLTQRLFSIRYQSLRQPHHGPQFGSEVELRHS
  
Inhibitor
Name:
BDBM50011192
Synonyms:
(R)-1-[(S)-2-((S)-1-Carboxy-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid | (S)-1-[(S)-2-((S)-1-Carboxy-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid | 1-((2S)-2-{[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO}PROPANOYL)-L-PROLINE | 1-(3-Mercapto-2-methyl-propionyl)-pyrrolidine-2-carboxylic acid | 1-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid | 1-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid (Enalaprilat) | 1-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid(Enalaprilat) | 1-[2-[1-carboxy-3-phenyl-(1S)-propylamino]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxylic acid(enalaprilat) | CHEMBL577 | ENALAPRILAT | Lexxel | Teczem | Vaseretic | Vasotec
Type:
Small organic molecule
Emp. Form.:
C18H24N2O5
Mol. Mass.:
348.3936
SMILES:
CC(NC(CCc1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O
Structure:
Search PDB for entries with ligand similarity: