Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM50025156
Substrate
n/a
Meas. Tech.
ChEBML_105117
Ki
2400000±n/a nM
Citation
 Lim, HKappler, FHai, TTHampton, A Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. J Med Chem 29:1743-8 (1986) [PubMed]  Article
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AdoMet synthetase 2 | MAT 2 | MAT-II | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-Adenosylmethionine Synthase (AdoMet) | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2
Type:
PROTEIN
Mol. Mass.:
43713.68
Organism:
Rattus norvegicus
Description:
ChEMBL_105118
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM50025156
Synonyms:
2-Amino-4-methylsulfanyl-pentanoic acid | CHEMBL45530
Type:
Small organic molecule
Emp. Form.:
C6H13NO2S
Mol. Mass.:
163.238
SMILES:
CSC(C)C[C@@H](N)C(O)=O
Structure:
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