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Target
Proprotein convertase subtilisin/kexin type 6
Ligand
BDBM50466078
Substrate
n/a
Meas. Tech.
ChEMBL_1789727 (CHEMBL4261461)
Ki
14±n/a nM
Citation
 Dianati, V; Navals, P; Couture, F; Desjardins, R; Dame, A; Kwiatkowska, A; Day, R; Dory, YL Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue. J Med Chem 61:11250-11260 (2018) [PubMed]  Article 
Target
Name:
Proprotein convertase subtilisin/kexin type 6
Synonyms:
PACE4 | PCSK6 | PCSK6_HUMAN | Subtilisin/kexin type 6
Type:
PROTEIN
Mol. Mass.:
106442.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1290742
Residue:
969
Sequence:
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG
  
Inhibitor
Name:
BDBM50466078
Synonyms:
CHEMBL4278214
Type:
Small organic molecule
Emp. Form.:
C51H91N15O8
Mol. Mass.:
1042.3639
SMILES:
CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(C(N)=N)c(N)c1 |r|
Structure:
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