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Target3-hydroxyacyl-CoA dehydrogenase type-2
LigandBDBM50466363
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1792852
IC50 610000±n/a nM
Citation Boutin, SRoy, JMaltais, RAlata, WCalon, FPoirier, D Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17?-hydroxysteroid dehydrogenase type 10. Bioorg Med Chem Lett28:3554-3559 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
3-hydroxyacyl-CoA dehydrogenase type-2
Name:3-hydroxyacyl-CoA dehydrogenase type-2
Synonyms:1.1.1.178 | 1.1.1.35 | 1.1.1.51 | 17-beta-HSD 10 | 17-beta-hydroxysteroid dehydrogenase 10 | 3-hydroxy-2-methylbutyryl-CoA dehydrogenase | 3-hydroxyacyl-CoA dehydrogenase type II | 3-hydroxyacyl-CoA dehydrogenase type-2 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Erab | Hadh2 | Hsd17b10 | Mitochondrial RNase P protein 2 | Mitochondrial ribonuclease P protein 2 | Type II HADH
Type:PROTEIN
Mol. Mass.:27421.83
Organism:Mus musculus
Description:ChEMBL_117895
Residue:261
Sequence:
MAAAVRSVKGLVAVVTGGASGPWLATAKRLVGQGATAVLLDVPDSEGESQAKKLGESCIF
APANVTSEKEIQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHQKKNKIHTLEDFQRVINV
NLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIDGMTL
PIARDLAPTGIRVVTIAPGLFATPLLTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQTI
IENPFLNGEVIRLDGAIRMQP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50466363
NameBDBM50466363
Synonyms:CHEMBL4277154
TypeSmall organic molecule
Emp. Form.C32H50N2O3
Mol. Mass.510.751
SMILES[H][C@@]12CC[C@@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@](O)(CN3CCN(Cc4cccc(OC)c4)CC3)CC[C@]12C |r|
Structure
n/a