Reaction Details Report a problem with these data
Target
Somatostatin receptor type 5
Ligand
BDBM50468146
Substrate
n/a
Meas. Tech.
ChEMBL_1798205 (CHEMBL4270322)
IC50
0.400000±n/a nM
Citation
 Liu, W; Hussain, Z; Zang, Y; Sweis, RF; Romero, FA; Finke, PE; Moningka, R; Bao, J; Plotkin, MA; Shang, J; Dingley, KH; Salituro, G; Murphy, BA; Howard, AD; Ujjainwalla, F; Wood, HB; Duffy, JL Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists. ACS Med Chem Lett 9:1088-1093 (2018) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 5
Synonyms:
SOMATOSTATIN SST5 | SS-5-R | SS5-R | SS5R | SSR5_HUMAN | SSTR5 | Somatostatin receptor type 5 (SSTR5)
Type:
Enzyme
Mol. Mass.:
39218.02
Organism:
Homo sapiens (Human)
Description:
P35346
Residue:
364
Sequence:
MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
  
Inhibitor
Name:
BDBM50468146
Synonyms:
CHEMBL4285917
Type:
Small organic molecule
Emp. Form.:
C25H24ClF3N2O4
Mol. Mass.:
508.917
SMILES:
OC(=O)c1ccc(cc1)N1CC2(CCN(Cc3cc(c(Cl)cc3C3CC3)C(F)(F)F)CC2)OC1=O
Structure:
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