Reaction Details Report a problem with these data
Target
Hydroxyacylglutathione hydrolase, mitochondrial
Ligand
BDBM50026368
Substrate
n/a
Meas. Tech.
ChEBML_71300
Ki
9000±n/a nM
Citation
 Bush, PE; Norton, SJ S-(nitrocarbobenzoxy)glutathiones: potent competitive inhibitors of mammalian glyoxalase II. J Med Chem 28:828-30 (1985) [PubMed]  Article 
Target
Name:
Hydroxyacylglutathione hydrolase, mitochondrial
Synonyms:
GLO2_RAT | Glyoxalase II | Hagh | Rsp29
Type:
PROTEIN
Mol. Mass.:
34116.42
Organism:
Rattus norvegicus
Description:
ChEMBL_71301
Residue:
309
Sequence:
MVLGRGSLCLRSLSVLGAACARRGLGQALLGLSLCHTDFRKNLTVQQDMMKIELLPALTDNYMYLIIDEDTQEAAVVDPVQPQKVIETVKKHRVKLTTVLTTHHHWDHAGGNEKLVKLEPGLKVYGGDDRIGALTHKVTHLSTLEVGSLSVKCLSTPCHTSGHICYFVSKPGSSEPSAVFTGDTLFVAGCGKFYEGTADEMYKALLEVLGRLPPDTKVICGHEYTVNNLKFARHVEPGNTAVQEKLAWAKEKNAIGEPTVPSTLAEEFTYNPFMRVKEKTVQQHAGETDPVTTMRAIRREKDQFKVPRD
  
Inhibitor
Name:
BDBM50026368
Synonyms:
2-Amino-4-[1-(carboxymethyl-carbamoyl)-2-(3-nitro-benzyloxycarbonylsulfanyl)-ethylcarbamoyl]-butyric acid | CHEMBL355031
Type:
Small organic molecule
Emp. Form.:
C18H22N4O10S
Mol. Mass.:
486.453
SMILES:
NC(CCC(=O)NC(CSC(=O)OCc1cccc(c1)[N+]([O-])=O)C(=O)NCC(O)=O)C(O)=O
Structure:
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