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Targetadrenergic Alpha2
LigandBDBM50019848
Substrate/Competitorn/a
Meas. Tech.ChEMBL_33031
Ki 1.5±n/a nM
Citation Saari, WSHalczenko, WKing, SWHuff, JRGuare, JPHunt, CARandall, WCAnderson, PSLotti, VJTaylor, DA Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists. J Med Chem26:1696-701 (1984) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
adrenergic Alpha2
Name:adrenergic Alpha2
Synonyms:Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha-2Da adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha2A | adrenergic Alpha2D
Type:Enzyme Catalytic Domain
Mol. Mass.:49275.13
Organism:BOVINE
Description:adrenergic Alpha2 0 BOVINE::Q28838
Residue:452
Sequence:
MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSG
QPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATA
AELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSS
EHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAK
ASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCN
SSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50019848
NameBDBM50019848
Synonyms:2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole | 4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1H-imidazole | CHEMBL10316 | Idazoxan | US8633208, Idazoxan
TypeSmall organic molecule
Emp. Form.C11H12N2O2
Mol. Mass.204.2252
SMILESC1CN=C(N1)C1COc2ccccc2O1 |c:2|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a