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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50026636
Substrate
n/a
Meas. Tech.
ChEBML_33092
Ki
940±n/a nM
Citation
 Saari, WS; Halczenko, W; King, SW; Huff, JR; Guare, JP; Hunt, CA; Randall, WC; Anderson, PS; Lotti, VJ; Taylor, DA Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists. J Med Chem 26:1696-701 (1984) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_BOVIN | ADRA1A | ADRA1C | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha-1C adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51492.08
Organism:
CALF
Description:
adrenergic Alpha1 0 CALF
Residue:
466
Sequence:
MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
  
Inhibitor
Name:
BDBM50026636
Synonyms:
17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic acid methyl ester | CHEMBL10347 | RAUWOLSCINE HYDROCHLORIDE | alpha-yohimbine | corynanthidine | isoyohimbine | mesoyohimbine | methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate | methyl 17alpha-hydroxy-20alpha-yohimban-16beta-carboxylate | rauwolscine
Type:
Small organic molecule
Emp. Form.:
C21H26N2O3
Mol. Mass.:
354.4427
SMILES:
COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Structure:
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