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Target
Neuropeptide S receptor
Ligand
BDBM50412707
Substrate
n/a
Meas. Tech.
ChEMBL_492704 (CHEMBL938504)
EC50
12±n/a nM
Citation
 Camarda, V; Trapella, C; Calo', G; Guerrini, R; Rizzi, A; Ruzza, C; Fiorini, S; Marzola, E; Reinscheid, RK; Regoli, D; Salvadori, S Structure-activity study at positions 3 and 4 of human neuropeptide S. Bioorg Med Chem 16:8841-5 (2008) [PubMed]  Article 
Target
Name:
Neuropeptide S receptor
Synonyms:
Gpr154 | NPSR1_MOUSE | Npsr1 | Pgr14
Type:
PROTEIN
Mol. Mass.:
42447.53
Organism:
Mus musculus
Description:
ChEMBL_445691
Residue:
371
Sequence:
MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALVAEEWGSFYSSFKTEQLITLWVLFVVTIVGNSVVLFSTCRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLAIISVIYGLVIRTIWMKSKTHETVISNCSDGKLCCSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFNVLPDTKERFYASVIIQNLPALNSAINPLIYCIFSSSICSPCKMQRSQDSRMTYRERSERHEMQILSKPEFI
  
Inhibitor
Name:
BDBM50412707
Synonyms:
CHEMBL230333
Type:
Small organic molecule
Emp. Form.:
C93H155N31O28S
Mol. Mass.:
2187.482
SMILES:
CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O |r|
Structure:
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