Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProtease
LigandBDBM50215393
Substrate/Competitorn/a
Meas. Tech.ChEMBL_544292
Ki 57±n/a nM
Citation Hazen, RHarvey, RFerris, RCraig, CYates, PGriffin, PMiller, JKaldor, IRay, JSamano, VFurfine, ESpaltenstein, AHale, MTung, RSt Clair, MHanlon, MBoone, L In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV. Antimicrob Agents Chemother51:3147-54 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protease
Name:Protease
Synonyms:n/a
Type:Enzyme
Mol. Mass.:10904.79
Organism:Human immunodeficiency virus 1 (HIV-1)
Description:Q9YQ12
Residue:99
Sequence:
PQITLWQRPFVTIKIEGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50215393
NameBDBM50215393
Synonyms:141 W94 | 141W94 | AMPRENAVIR | Agenerase | Amprenavir | CHEBI:40050 | KVX-478 | VX-478
TypeSmall organic molecule
Emp. Form.C25H35N3O6S
Mol. Mass.505.627
SMILESCC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1 |r|
Structure
n/a