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Target
Substance-P receptor
Ligand
BDBM50029859
Substrate
n/a
Meas. Tech.
ChEMBL_208660 (CHEMBL813320)
IC50
7230±n/a nM
Citation
 Swain, CJ; Seward, EM; Cascieri, MA; Fong, TM; Herbert, R; MacIntyre, DE; Merchant, KJ; Owen, SN; Owens, AP; Sabin, V Identification of a series of 3-(benzyloxy)-1-azabicyclo[2.2.2]octane human NK1 antagonists. J Med Chem 38:4793-805 (1996) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46371.54
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:
407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
  
Inhibitor
Name:
BDBM50029859
Synonyms:
1-Ethyl-2-{(E)-3-[1-ethyl-3,3-dimethyl-1,3-dihydro-indol-(2E)-ylidene]-propenyl}-1H-imidazo[4,5-b]quinoxaline | CHEMBL145407
Type:
Small organic molecule
Emp. Form.:
C26H27N5
Mol. Mass.:
409.5261
SMILES:
CCN1\C(=C\C=C\c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc12
Structure:
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