Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50030019
Substrate
n/a
Meas. Tech.
ChEMBL_1094 (CHEMBL616417)
Ki
1.7±n/a nM
Citation
 Liu, YYu, HSvensson, BECortizo, LLewander, THacksell, U Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors. J Med Chem 36:4221-9 (1994) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50030019
Synonyms:
(S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1-carboxylic acid methyl ester | 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1-carboxylic acid methyl ester | CHEMBL316050
Type:
Small organic molecule
Emp. Form.:
C18H27NO2
Mol. Mass.:
289.4125
SMILES:
CCCN(CCC)[C@H]1CCc2cccc(C(=O)OC)c2C1
Structure:
Search PDB for entries with ligand similarity: