Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50011261
Substrate
n/a
Meas. Tech.
ChEMBL_1172 (CHEMBL615844)
Ki
2.9±n/a nM
Citation
 Liu, Y; Yu, H; Mohell, N; Nordvall, G; Lewander, T; Hacksell, U Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists. J Med Chem 38:150-60 (1995) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50011261
Synonyms:
(+)7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrochloride | (-)7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrochloride | 7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrochloride | CHEMBL43475 | CHEMBL544757
Type:
Small organic molecule
Emp. Form.:
C17H27NO
Mol. Mass.:
261.4024
SMILES:
CCCN(CCC)[C@@H]1CCc2cccc(O)c2[C@@H]1C
Structure:
Search PDB for entries with ligand similarity: