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Target
Substance-P receptor
Ligand
BDBM50030605
Substrate
n/a
Meas. Tech.
ChEMBL_205727 (CHEMBL809494)
IC50
68±n/a nM
Citation
 Natsugari, H; Ikeura, Y; Kiyota, Y; Ishichi, Y; Ishimaru, T; Saga, O; Shirafuji, H; Tanaka, T; Kamo, I; Doi, T Novel, potent, and orally active substance P antagonists: synthesis and antagonist activity of N-benzylcarboxamide derivatives of pyrido[3,4-b]pyridine. J Med Chem 38:3106-20 (1995) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50030605
Synonyms:
CHEMBL326889 | N-(3,5-Bis-trifluoromethyl-benzyl)-N-methyl-2-(2-methyl-1-oxo-4-phenyl-1,2-dihydro-isoquinolin-3-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C28H22F6N2O2
Mol. Mass.:
532.4769
SMILES:
CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C
Structure:
Search PDB for entries with ligand similarity: