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Target
Type-2 angiotensin II receptor
Ligand
BDBM50030726
Substrate
n/a
Meas. Tech.
ChEMBL_35413 (CHEMBL643587)
IC50
0.190000±n/a nM
Citation
 Chang, LL; Ashton, WT; Flanagan, KL; Chen, TB; O'Malley, SS; Zingaro, GJ; Kivlighn, SD; Siegl, PK; Lotti, VJ; Chang, RS Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes. J Med Chem 38:3741-58 (1995) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50030726
Synonyms:
3-[4-(2'-Benzoylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-5-oxo-3-propyl-4,5-dihydro-[1,2,4]triazol-1-yl]-N-propyl-4-trifluoromethyl-benzamide | CHEMBL331450
Type:
Small organic molecule
Emp. Form.:
C36H33F4N5O5S
Mol. Mass.:
723.736
SMILES:
CCCNC(=O)c1ccc(c(c1)-n1nc(CCC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)c1=O)C(F)(F)F
Structure:
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