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Target
Trehalase
Ligand
BDBM18353
Substrate
n/a
Meas. Tech.
ChEMBL_208284 (CHEMBL813582)
IC50
28000±n/a nM
Citation
 Asano, N; Kizu, H; Oseki, K; Tomioka, E; Matsui, K; Okamoto, M; Baba, M N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication. J Med Chem 38:2349-56 (1995) [PubMed]  Article 
Target
Name:
Trehalase
Synonyms:
Alpha,alpha-trehalase
Type:
PROTEIN
Mol. Mass.:
63480.07
Organism:
Rattus norvegicus
Description:
ChEMBL_208284
Residue:
557
Sequence:
ALSPLCESQIYCHGELLHQVQMAQLYQDDKQFVDMSLATSPDEVLQKFSELAVAHNHSIPREELQNFVQSYFQPVGQELQPWTPEDWKDSPQFLQKISDSRLRVWAEELHKIWKKLGKKMKAEVLSHPERSSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHIPNGGRVYYLQRSHPPLLTLMMERYVAHTNDVAFLRENIGTLALELEFWTVNRTVSVGSGGQSYILNRYYVPYGGPRPESYSKDEELAKTVPEGDRETLWAELKAGAESGWDFSSRWLVGGPDPDLLSSIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEAKRYRNLRAQRLAAMEAILWDEQKGAWFDYDLEKGKKNLEFYPSNLTPLWAGCFSDPNVADRALKYLEDNKILTYQYGIPTSLRNTGQQWDFPNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNRIKTNFKVYSQKSAMYEKYDISNGGHPGGGGEYEVQEGFGWTNGLALMLLDRYGDQLTSGTQLASLGPHCLVTALLLSLLLQ
  
Inhibitor
Name:
BDBM18353
Synonyms:
(2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine-3,4,5-triol | CHEMBL75971 | N-Methyl-DNJ | US9181184, 2
Type:
natural product
Emp. Form.:
C7H15NO4
Mol. Mass.:
177.1983
SMILES:
CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Structure:
Search PDB for entries with ligand similarity: