Target
Presenilin-1
Ligand
BDBM50489349
Substrate
n/a
Meas. Tech.
ChEMBL_933737 (CHEMBL2320839)
IC50
0.900000±n/a nM
Citation
 Wu, WLAsberom, TBara, TBennett, CBurnett, DAClader, JDomalski, MGreenlee, WJJosien, HMcBriar, MRajagopalan, MVicarel, MXu, RHyde, LADel Vecchio, RACohen-Williams, MESong, LLee, JTerracina, GZhang, QNomeir, AParker, EMZhang, L Structure activity relationship studies of tricyclic bispyran sulfone ?-secretase inhibitors. Bioorg Med Chem Lett 23:844-9 (2013) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50489349
Synonyms:
CHEMBL2314606
Type:
Small organic molecule
Emp. Form.:
C22H23ClF2O7S2
Mol. Mass.:
536.994
SMILES:
[H][C@@]12COc3c(F)ccc(F)c3[C@@]1(CCO[C@H]2CCS(=O)(=O)CCO)S(=O)(=O)c1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: