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Target
Presenilin-1
Ligand
BDBM50489342
Substrate
n/a
Meas. Tech.
ChEMBL_933739 (CHEMBL2320841)
IC50
1.4±n/a nM
Citation
 Wu, WL; Asberom, T; Bara, T; Bennett, C; Burnett, DA; Clader, J; Domalski, M; Greenlee, WJ; Josien, H; McBriar, M; Rajagopalan, M; Vicarel, M; Xu, R; Hyde, LA; Del Vecchio, RA; Cohen-Williams, ME; Song, L; Lee, J; Terracina, G; Zhang, Q; Nomeir, A; Parker, EM; Zhang, L Structure activity relationship studies of tricyclic bispyran sulfone ?-secretase inhibitors. Bioorg Med Chem Lett 23:844-9 (2013) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50489342
Synonyms:
CHEMBL2314603
Type:
Small organic molecule
Emp. Form.:
C23H21ClF2N2O6S2
Mol. Mass.:
559.002
SMILES:
[H][C@@]12COc3c(F)ccc(F)c3[C@@]1(CCO[C@H]2CCS(=O)(=O)c1ncc[nH]1)S(=O)(=O)c1ccc(Cl)cc1 |r|
Structure:
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